Validation of a New RP-HPLC Method for Determination of Hydrocortisone Acetate Complexed with HPβCD in a Oral Liquid Pharmaceutical Preparation
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چکیده
Hydrocortisone acetate (HA) is a synthetic corticosteroid and is usually employed in the treatment of classic congenital adrenal hyperplasia (CAH), which is a disorder of the adrenal cortex characterized by cortisol deficiency, with or without aldosterone deficiency, and androgen excess [1]. Because five enzymatic steps are involved in cortisol biosynthesis, there are five distinct CAH syndromes [2]. Approximately 95 percent of cases are due to 21-hydroxylase deficiency [3]. The clinical features are; virilization, rapid somatic growth and accelerated skeletal maturation [4].
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